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Your Vote Counts! KEZAR LIFE SCIENCES, INC. 2023 Annual Meeting Vote by June 13, 2023 11:59 PM ET KEZAR LIFE SCIENCES, INC. 4000 SHORELINE COURT, SUITE 300 SOUTH SAN FRANCISCO, CA 94080 V14649-P94405

You invested in KEZAR LIFE SCIENCES, INC. and it’s time to vote! You have the right to vote on proposals being presented at the Annual Meeting. This is an important notice regarding the availability of proxy material for the stockholder meeting to be held on June 14, 2023. Get informed before you vote View the Notice and Proxy Statement and Form 10-K online OR you can receive a free paper or email copy of the material(s) by requesting prior to May 31, 2023. If you would like to request a copy of the material(s) for this and/or future stockholder meetings, you may (1) visit, (2) call 1-800-579-1639 or (3) send an email to If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. For complete information and to vote, visit Control # Vote in Person at the Meeting* June 14, 2023 1:00 PM PDT Smartphone users Point your camera here and vote without entering a control number 4000 Shoreline Court Suite 300 South San Francisco, CA 94080 *Please check the meeting materials for any special requirements for meeting attendance. At the meeting, you will need to request a ballot to vote these shares. 

V1.2 Vote at THIS IS NOT A VOTABLE BALLOT This is an overview of the proposals being presented at the upcoming stockholder meeting. Please follow the instructions on the reverse side to vote these important matters. Board Recommends Voting Items 1. Election of Directors Nominees: 1a. Franklin Berger For For 1b. Graham Cooper For 1c. Micki Klearman, M.D. 2. Ratification of the selection of KPMG LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2023. For 3. Approval of an amendment to the Company’s amended and restated certificate of incorporation to increase the number of authorized shares of common stock from 125,000,000 shares to 250,000,000 shares. For NOTE: Such other matters properly brought before the Annual Meeting. Prefer to receive an email instead? While voting on, be sure to click “Delivery Settings”. V14650-P94405